abstract：:The hypothesis has been tested that an unusual maternal acetylator phenotype can predispose to congenital malformations in the fetus. The acetylator phenotype of normal caucasian control women and of mothers of malformed children was established by measuring urinary sulphadimidine and its acetylated metabolite. A furt...

journal_title：European journal of clinical pharmacology

authors： Stoll C,Roth MP,Dott B,Doumit N,Alembik Y,Welsch M,Imbs JL

更新日期：1989-01-01 00:00:00

abstract：:Intensive monitoring of adverse drug reactions (ADR) in infants and preschool children in the paediatric outpatient unit covering the town of Karlovac (150,000 inhabitants) was performed over a period of three months. Data were obtained by physical examination of children and the history given by their parents. In all...

journal_title：European journal of clinical pharmacology

authors： Cirko-Begović A,Vrhovac B,Bakran I

更新日期：1989-01-01 00:00:00

abstract：:We have studied the transfer of the analgesic ketorolac tromethamine into breast milk in ten women aged between 22 and 35 years. Ketorolac administration was started between 2 and 6 days after delivery. The breast milk was not fed to the infant because of maternal antibiotic use (6 patients) or because of jaundice of ...

journal_title：European journal of clinical pharmacology

authors： Wischnik A,Manth SM,Lloyd J,Bullingham R,Thompson JS

更新日期：1989-01-01 00:00:00

abstract：:The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (...

journal_title：European journal of clinical pharmacology

authors： Chan GL,Erdmann GR,Gruber SA,Stock P,Chen S,Ascher NL,Canafax DM

更新日期：1989-01-01 00:00:00

abstract：:The effects on renal hemodynamics and salt-water handling of equipotent doses of the cardioselective beta-blocker metoprolol (M, 100 mg) and of the non-selective (intrinsic sympathetic activity) beta-antagonist pindolol (P, 10 mg) were compared in 30 WHO Grade 1-2 hypertensive men. M lowered pulse rate more than P. Sy...

journal_title：European journal of clinical pharmacology

authors： Koch G,Fransson L,Karlegärd L,Kothari P

更新日期：1989-01-01 00:00:00

abstract：:The pharmacokinetics of mexiletine, a Class I antiarrhythmic drug, was investigated in 6 healthy volunteers after single oral doses and 15 min intravenous infusions of 3 mg/kg. Cimetidine and ranitidine are commonly used H2-receptor antagonists, which interact adversely with many drugs, e.g. inhibition of the metaboli...

journal_title：European journal of clinical pharmacology

authors： Brockmeyer NH,Breithaupt H,Ferdinand W,von Hattingberg M,Ohnhaus EE

更新日期：1989-01-01 00:00:00

abstract：:To assess the partial agonist activity of cicloprolol in man, four studies were carried out in normal male volunteers. I and II. Open dose escalating studies of the effects of oral doses of the drug on exercise tachycardia and sleeping heart rate. III and IV. Double-blind randomized studies of the effects of placebo, ...

journal_title：European journal of clinical pharmacology

authors： McCaffrey PM,Burke M,Riddell JG,Shanks RG

更新日期：1988-01-01 00:00:00

abstract：:The relationship between the pharmacokinetics and pharmacodynamics of enoximone, a new positive inotropic agent, was investigated in 6 healthy men. The volunteers received single oral and i.v. doses of 3 and 1 mg/kg, respectively, and placebo in a double-blind cross-over trial. Plasma concentrations of enoximone and i...

journal_title：European journal of clinical pharmacology

authors： Belz GG,Meinicke T,Schäfer-Korting M

更新日期：1988-01-01 00:00:00

abstract：:We have studied the kinetics of a single oral dose of mefloquine (750 mg) in 12 Thai patients with falciparum malaria and have compared the results with those of a previous study in 12 healthy Thai volunteers. All the patients responded to treatment with a mean parasite clearance time of 66.6 h and a mean fever cleara...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Back DJ,Bunnag D,Breckenridge AM

更新日期：1988-01-01 00:00:00

abstract：:In a double-blind cross-over study bepridil 900 mg followed by 300 mg daily for 11 days was given to 37 insulin (Type I) or non-insulin (Type II)-dependent diabetic patients. It did not modify the metabolic control of the patients as levels of glucose in blood and urine, doses of insulin and oral hypoglycaemic drugs, ...

journal_title：European journal of clinical pharmacology

authors： Husted SE,Pedersen C,Nielsen HK,Apoil E,Nielsen OH,Lindvig K,Krusell LR,Høegholm A

更新日期：1988-01-01 00:00:00

abstract：:Cimetropium bromide is an antimuscarinic compound with antispasmodic properties. Its effect on meal-stimulated sigmoid motor activity in 30 patients with the irritable bowel syndrome, mainly with pain and constipation, has been evaluated. The mechanical activity of the sigmoid colon was recorded with a probe with thre...

journal_title：European journal of clinical pharmacology

authors： Lanfranchi GA,Bazzocchi G,Campieri M,Brignola C,Fois F,Imbimbo BP

更新日期：1988-01-01 00:00:00

abstract：:Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract ...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP,Forfang K

更新日期：1988-01-01 00:00:00

abstract：:In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. ...

journal_title：European journal of clinical pharmacology

authors： Lombardi C,Missale C,De Cotiis R,Spedini C,Pizzoccolo G,Memo M,Albertini A,Spano PF

更新日期：1988-01-01 00:00:00

abstract：:The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224-928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 ...

journal_title：European journal of clinical pharmacology

authors： Giani P,Landolina M,Giudici V,Bianchini C,Ferrario G,Marchi S,Riva E,Latini R

更新日期：1988-01-01 00:00:00

abstract：:The effects of short-term lithium (Li) administration on alpha 2-adrenoceptor sensitivity was studied in 10 healthy volunteers and in 15 patients with normothymic, phasic depressive disorders. The GH-clonidine test was used to examine alpha 2-adrenoceptor sensitivity, administered before and after Li treatment (600 mg...

journal_title：European journal of clinical pharmacology

authors： Brambilla F,Catalano M,Lucca A,Smeraldi E

更新日期：1988-01-01 00:00:00

abstract：:Atropine-induced bradycardia is traditionally ascribed to central vagal stimulation, although bradycardia has also been observed after administration of quarternary amines. Pirezepine, a selective M1-antagonist, causes bradycardia in therapeutic doses for which a peripheral mechanism is postulated. This hypothesis has...

journal_title：European journal of clinical pharmacology

authors： Meyer EC,Sommers DK

更新日期：1988-01-01 00:00:00

abstract：:In order to assess whether dinnertime administration of a once daily dose of famotidine is more advantageous than a bedtime dose in suppressing evening and nocturnal gastric acidity, we gave nine patients with a past history of duodenal ulcer in double-blind, randomized fashion either (1) placebo at 6 p.m. and 10 p.m....

journal_title：European journal of clinical pharmacology

authors： Savarino V,Mela GS,Scalabrini P,Fera G,Zentilin P,Sumberaz A,Celle G

更新日期：1988-01-01 00:00:00

abstract：:Eighty patients recovering from major operations were investigated to evaluate the influence of naloxone on the analgesic and respiratory depressant properties of buprenorphine. They were randomly assigned to two groups to self-administer either buprenorphine (Group B) or a mixture of buprenorphine and naloxone (fract...

journal_title：European journal of clinical pharmacology

authors： Lehmann KA,Reichling U,Wirtz R

更新日期：1988-01-01 00:00:00

abstract：:Drug utilization was studied in children below 14 years of age in Tenerife, Canary Islands, who were seen as outpatients by 15 paediatricians and 10 general practitioners. Data on diagnosis, previous drug exposure and prescriptions were collected from a random sample of 1327 children. Nose and throat infections (40.1%...

journal_title：European journal of clinical pharmacology

authors： Sanz EJ,Boada JN

更新日期：1988-01-01 00:00:00

abstract：:Antibiotic cost information was added to the computerized print-out for each patient of microbiology culture results, next to the antibiotic susceptibility list. During the first six months of this addition, the average monthly cost of antibiotics decreased by 16.5% ($7636) compared to the 12 months period preceding t...

journal_title：European journal of clinical pharmacology

authors： Rubinstein E,Barzilai A,Segev S,Samra Y,Modan M,Dickerman O,Haklai C

更新日期：1988-01-01 00:00:00

abstract：:We have studied 16 healthy men to evaluate preliminary pharmacodynamics and kinetics of BW443C given by i.v. infusions. Four volunteers received escalating doses at weekly intervals, starting at 0.1 microgram.kg-1 for 60 min and increasing to a maximum of 2.0 micrograms.kg-1.min-1 for 180 min. Subsequently 12 differen...

journal_title：European journal of clinical pharmacology

authors： Posner J,Dean K,Jeal S,Moody SG,Peck AW,Rutter G,Telekes A

更新日期：1988-01-01 00:00:00

abstract：:The pharmacokinetics of ceftazidime have been investigated after single and multiple i.v. doses in 9 young healthy male volunteers and 15 elderly male patients with acute bacterial infections. All subjects had normal, age-correlated glomerular function. Distribution and elimination in young volunteers were unaffected ...

journal_title：European journal of clinical pharmacology

authors： Ljungberg B,Nilsson-Ehle I

更新日期：1988-01-01 00:00:00

abstract：:The effects of acute and chronic administration of a slow-release preparation of pinacidil have been studied in eight normotensive volunteers aged 40-57 years. Continuous administration of 20 mg b.i.d. pinacidil had no effect on serum pinacidil concentrations measured as AUC (0-9 h), but accumulation of the principal ...

journal_title：European journal of clinical pharmacology

authors： McBurney A,Henry JA,Ward JW

更新日期：1988-01-01 00:00:00

abstract：:An open, dose-titration study of alfuzosin, a new selective post-synaptic alpha 1-adrenoceptor antagonist with additional direct vasodilator properties has been performed. After a 3-week run-in placebo period, 12 patients with essential hypertension received alfuzosin 5 mg oral b.d., and then the dose was doubled ever...

journal_title：European journal of clinical pharmacology

authors： Leto di Priolo S,Priore P,Cocco G,Sfrisi C,Cazor JL

更新日期：1988-01-01 00:00:00

abstract：:The possible interaction between cetirizine 2 HCl and alcohol was studied in a double-blind, cross-over trial in 36 healthy volunteers. The performance of each volunteer was tested with a battery of five objective psychometric tests, and their subjective feelings were evaluated by visual analogue scales, and by extens...

journal_title：European journal of clinical pharmacology

authors： Doms M,Vanhulle G,Baelde Y,Coulie P,Dupont P,Rihoux JP

更新日期：1988-01-01 00:00:00

abstract：:Seven healthy women chronically (greater than 6 months) treated with oral contraceptives and 7 age- and weight-matched female controls were studied. Each subject was given 20 mg fluocortolone orally and the plasma concentrations of total and unbound fluocortolone in multiple samples obtained during the following 24 h ...

journal_title：European journal of clinical pharmacology

authors： Legler UF

更新日期：1988-01-01 00:00:00

abstract：:The comparative enzyme inducing effects of rifabutin and the chemically related drug rifampicin have been investigated in 8 normal subjects. Rifampicin 600 mg daily for 7 days caused considerable shortening of the antipyrine half-life and a marked increase in antipyrine clearance, associated with an increased rate of ...

journal_title：European journal of clinical pharmacology

authors： Perucca E,Grimaldi R,Frigo GM,Sardi A,Mönig H,Ohnhaus EE

更新日期：1988-01-01 00:00:00

abstract：:The pharmacokinetics of fluocortolone and its effect on the circadian rhythm of plasma cortisol and ACTH have been studied during different schedules of oral administration. Groups of 6 healthy male adults were given a single daily dose of fluocortolone 5, 10 and 20 mg, and another group received 20 mg every second da...

journal_title：European journal of clinical pharmacology

authors： Tüber U,Posern U,Bickel U,Matthes H,Voigt K

更新日期：1988-01-01 00:00:00

abstract：:As a target group, geriataric patients were selected for pharmacokinetic studies with terodiline (Mictrol), an anticholinergic and calcium antagonist drug effective in the treatment of urinary incontinence. The single-dose kinetics in the geriatric patients (mean age 82 years) differed significantly from that previous...

journal_title：European journal of clinical pharmacology

authors： Hallén B,Magnusson A,Bogentoft S,Ekelund P

更新日期：1988-01-01 00:00:00

abstract：:We have compared the effect on ventilation of ketorolac, an injectable non-steroidal analgesic, with that of morphine in a randomized, double-blind, cross-over study, using two doses of ketorolac (10 and 90 mg i.m.) and one of morphine (10 mg i.m.). The effect on ventilation was measured with a CO2 rebreathing techniq...

journal_title：European journal of clinical pharmacology

authors： Bravo LJ,Mattie H,Spierdijk J,Bovill JG,Burm AG

更新日期：1988-01-01 00:00:00

abstract：:The effect beta-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1-6 mg, alternating with saline, in a ...

journal_title：European journal of clinical pharmacology

authors： Colombo F,Sega R,Mailland F,Rigo R,Palvarini L,Libretti A

更新日期：1988-01-01 00:00:00

abstract：:The effects of guar gum (GG) and microcrystalline cellulose (MC) on metabolic control and serum lipids were compared in a double-blind, cross-over trial in 18 poorly controlled Type 2 diabetic patients. There were two 12 week treatment periods separated by a 4 week wash-out period. A significant reduction in fasting B...

journal_title：European journal of clinical pharmacology

authors： Niemi MK,Keinänen-Kiukaanniemi SM,Salmela PI

更新日期：1988-01-01 00:00:00

abstract：:Pharmacokinetic interactions between antipyrine and acetaminophen were evaluated in 7 healthy volunteers. On 3 occasions subjects received: 1, antipyrine 1.0 g intravenously (i.v.); 2, acetaminophen 650 mg i.v.; 3, antipyrine 1.0 g and acetaminophen 650 mg i.v. simultaneously. Between Trials 1 and 3, antipyrine elimin...

journal_title：European journal of clinical pharmacology

authors： Blyden GT,Greenblatt DJ,LeDuc BW,Scavone JM

更新日期：1988-01-01 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic properties of a new controlled-release (CR) formulation of metoprolol have been compared with those of atenolol. Metoprolol CR (100 mg and 200 mg), atenolol (50 mg and 100 mg) and placebo were each given once daily for four days in a double-blind, cross-over study to ten healthy men...

journal_title：European journal of clinical pharmacology

authors： Blomqvist I,Westergren G,Sandberg A,Jonsson UE,Lundborg P

更新日期：1988-01-01 00:00:00

abstract：:The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Reiner A,Arrigoni Martelli E,Conte U,Colombo P,La Manna A

更新日期：1987-01-01 00:00:00

abstract：:Sixty patients were treated for 1 year for essential uncomplicated hypertension, 30 with beta-blockers alone (BB) and 30 with BB and chlorthalidone (CTD). BB did not affect serum K+ or Mg++. In the BB-group there was a statistically significant trend towards retention of Mg++ in a loading test, but the effect was clin...

journal_title：European journal of clinical pharmacology

authors： Cocco G,Iselin HU,Strozzi C,Cesana B,Baumeler HR

更新日期：1987-01-01 00:00:00

abstract：:The effect of pentobarbital treatment in a mean dose of 30 mg/kg/day on the clearance of hexobarbital (Evipan) and dipyrone (Novalgin) has been evaluated in critical care patients receiving a large number of drugs as comedication. Eleven patients treated with pentobarbital showed a hexobarbital half-life of 2.79 h and...

journal_title：European journal of clinical pharmacology

authors： Heinemeyer G,Gramm HJ,Simgen W,Dennhardt R,Roots I

更新日期：1987-01-01 00:00:00

abstract：:We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are ...

journal_title：European journal of clinical pharmacology

authors： Tett SE,Cutler DJ

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics of theophylline was investigated in five hyperthyroid, five hypothyroid, and five euthyroid patients, all with chronic obstructive pulmonary disease. Wide individual variability was found in theophylline kinetics, but the rate of elimination of theophylline was significantly higher in hyperthyroid...

journal_title：European journal of clinical pharmacology

authors： Pokrajac M,Simić D,Varagić VM

更新日期：1987-01-01 00:00:00

abstract：:Infusion of a therapeutic dose of sparteine sulphate, increased the basal plasma insulin level and lowered plasma glucose. When an intravenous glucose tolerance test was performed with the infusion, the total insulin AUC was significantly larger than in absence of sparteine (2025 vs 1464 microU/ml X min), plasma gluco...

journal_title：European journal of clinical pharmacology

authors： Sgambato S,Paolisso G,Passariello N,Varricchio M,D'Onofrio F

更新日期：1987-01-01 00:00:00